Citation: Jing Li Cheng, Yong Zhou, Jin Hao Zhao, Chulong Zhang, Fu Cheng Lin. Synthesis and antifungal activity of trichodermin derivatives[J]. Chinese Chemical Letters, ;2010, 21(9): 1037-1040. doi: 10.1016/j.cclet.2010.04.033 shu

Synthesis and antifungal activity of trichodermin derivatives

Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou 310029, China

Received Date: 22 December 2009

Fund Project: This work is financially supported by National Natural Science Foundation of China (No.30700532) and the Science and Technology Project of Zhejiang province (No.2008C02007-3).

A series of derivatives were synthesized from trichodermin (1) which was an antifungal metabolite produced by Trichoderma taxi sp. nov. Their structures were confirmed by ¹H NMR, MS spectrum. Their antifungal activities were evaluated in vitro. The preliminary structure activity relationships (SAR) results indicated that the double bond, epoxide moiety and ester group were main pharmacophore elements, the stereochemistry of C4 position played a key role as well, and the compounds 1e-1g displayed stronger antifungal activity against Magnaporthe grisea than 1.
- Trichodermin derivatives,
- Synthesis,
- Antifungal activity
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