Citation: Pu Yong Zhang, Jun Lei Wang, Sheng Biao Wan, Tao Jiang. First total synthesis of eudistalbin A[J]. Chinese Chemical Letters, ;2010, 21(8): 889-891. doi: 10.1016/j.cclet.2010.03.017 shu

First total synthesis of eudistalbin A

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China

Received Date: 25 December 2009

Fund Project: We are grateful for the financial support of Key International S&T Cooperation Projects of MOST (No. 2008DFA31040).

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED₅₀ < 3.2μg/mL) in vitro against the growth of KB human buccal carinoma cells. The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC₅₀ value of 2.1 μmol/L using the metabolic assay MTT. All structures of new compounds were confirmed by ¹H NMR, ¹³C NMR, HRMS and optical rotation.
- β-Carboline,
- Eudistalbin A,
- Pictet-Spengler reaction,
- Henry reaction,
- Total synthesis
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