Citation: Bao Liu, Qi Dong You, Zhi Yu Li. Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives[J]. Chinese Chemical Letters, ;2010, 21(5): 554-557. doi: 10.1016/j.cclet.2010.01.016 shu

Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 15 September 2009

Fund Project: The work was supported by National Natural Science Foundation of China (No. 30371676).

A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives (12a-l) were synthesized. The cytotoxicity of 12 new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. The results showed that compounds 12g,12h, 12i, 12k and 12l displayed more potent cytotoxic activities than Bosutinib, compound 12l exhibited the most potent antitumor activity among the tested compounds.
- 3-Quinolinecarbonitrile derivatives,
- Synthesis,
- Antitumor
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