Citation: Nida N. Farshori, Mudasir R. Banday, Zeeshan Zahoor, Abdul Rauf. DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol: In vitro antimicrobial activity[J]. Chinese Chemical Letters, ;2010, 21(6): 646-650. doi: 10.1016/j.cclet.2010.01.003 shu

DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol: In vitro antimicrobial activity

a Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India;
b Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India

Received Date: 6 November 2009

Fund Project: The authors thank the Chairman, Department of Chemistry, AMU, Aligarh, for providing necessary facilities and SAIF Panjab University, Chandigarh for recording the spectra.

A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral data. All the synthesized compounds were evaluated for their in vitro antimicrobial activity. The minimum inhibitory concentration (MIC), minimum bacterial concentration (MBC) and minimum fungicidal concentration (MFC) were determined for test compounds as well as for reference standards. Among the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities.
- Fatty acids,
- β-Sitosterol,
- DCC,
- DMAP,
- IR,
- NMR,
- Mass,
- Antimicrobial activity
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