Citation: Geng Xu, Zhan Zhu Liu. Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tetrahydroisoquinoline β-amino alcohol[J]. Chinese Chemical Letters, ;2010, 21(3): 309-311. doi: 10.1016/j.cclet.2009.11.046 shu

Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tetrahydroisoquinoline β-amino alcohol

Geng Xu ,
Zhan Zhu Liu

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine(Peking Union Medical College), Ministry of Education. Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China

Received Date: 14 July 2009

A highly effective, new chiral 1,2,3,4-tetrahydroisoquinoline catalyst 1 for the diethylzinc addition to aryl aldehydes has been investigated. Using 10 mo1% of this chiral catalyst, secondary alcohols can be obtained in up to 87% yield and 99.5% ee under mild conditions.
- β-Amino alcohol,
- Tetrahydroisoquinoline,
- Diethylzinc,
- Asymmetric addition
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