Citation: Xi Cun Wang, Xiao Mei Ding, Sheng Qing Wang, Xue Fei Chen, Zheng Jun Quan. Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400[J]. Chinese Chemical Letters, ;2010, 21(3): 301-304. doi: 10.1016/j.cclet.2009.11.045 shu

Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400

Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Received Date: 14 July 2009

Fund Project: We are thankful for the financial support from the Natural Science Foundation of Gansu Province (No. 3ZS061-A25-019), the Scientific Research fund of Gansu Provincial Education Department(No. 0601-25).

An environmental benign procedure for synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles has been developed by reaction of 2-amino-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with formic acid in PEG-400. The key advantages of this protocol are the shorter reaction time, higher yields, lower cost, simple workup, and environment-friendly compared to conventional organic solvent reaction. The present method does not involve any hazardous organic solvent or catalyst.
- 2-(N-Formyl)-5-atyl/aryloxymethyl-1,3,4-thiadiazoles,
- 2-Amino-5-aryl/aryloxymethyl-l,3,4-thiadiazoles,
- PEG-400,
- Synthesis
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