Citation: Guo Hua Chen, Sheng Wang, Fei Hua Wu. A practical synthesis of sarpogrelate hydrochloride and in vitro platelet aggregation inhibitory activities of its analogues[J]. Chinese Chemical Letters, ;2010, 21(3): 287-289. doi: 10.1016/j.cclet.2009.11.030 shu

A practical synthesis of sarpogrelate hydrochloride and in vitro platelet aggregation inhibitory activities of its analogues

a Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;
b Department of Pharmacology for Chinese Materia Medica, China Pharmaceutical University, Nanjing 210038, China

Received Date: 3 July 2009

A convenient approach for the preparation of sarpogrelate hydrochloride was developed. Two series of sarpogrelate hydrochloride analogues were designed and synthesized in order to improve their platelet aggregation inhibitory activities, biological tests suggested that these compounds have platelet aggregation inhibitory activities to some extent.
- Sarpogrelate hydrochloride,
- Platelet aggregation inhibitor,
- Synthesis
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