Citation: Peng Cho Tang, Zhi Gang Lin, Yang Wang, Fang Long Yang, Qian Wang, Jian Hong Fu, Lei Zhang, Ai Shen Gong, Jing Jing Luo, Jun Dai, Gao Hong She, Dan Dan Si, Jun Feng. Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes[J]. Chinese Chemical Letters, ;2010, 21(3): 253-256. doi: 10.1016/j.cclet.2009.11.014 shu

Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes

Shanghai Hengrui Pharmaceuticals Co. Ltd., 279 Wenjing Road, Shanghai 200245, China

Received Date: 31 August 2009

Fund Project: The authors thank Mr. Sun Piao Yang for his vision and support in new drug discovery in China, Dr.Wang Wei Bo for ideas and suggestions on the initial phase of the synthesis, and Mr. Wu Qian of Analytical Chemistry Group of Shanghai Hengrui Pharmaceuticals Co., Ltd. for 1H NMR and mass spectroscopy services.

An efficient stereoselective synthesis of the rigid aza-bicyclo[3.2.0]heptane scaffold has been developed to provide 2-cyano-pyrrolidine alpha-amino amide 1 as DPP-4 inhibitor.
- DPP-4 inhibitor,
- Aza-bicyclo[3.2.0]heptane scaffold,
- 2-Cyaaopyrrolidine alpha-amino amide derivative,
- Synthesis,
- Type 2 diabetes
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