Citation: Yan Dai, Bin Dong Li, Heng Dao Quan, Chun Xu Luä. CeCl₃·7H₂O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction[J]. Chinese Chemical Letters, ;2010, 21(1): 31-34. doi: 10.1016/j.cclet.2009.08.011 shu

CeCl₃·7H₂O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction

a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
b National Institute of Advanced Industrial Science and Technology, Ibaraki 3058565, Japan

Received Date: 13 May 2009

Fund Project: We are grateful for the financial support from Nanjing University of Science and Technology.

Cerium trichloride heptahydrate (CeCl₃·7H₂O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone. This protocol has advantages of high yield, no environmental pollution, mild condition, and simple work-up procedure.
- Cerium trichloride heptahydrate,
- Mannich reaction,
- β-Amino ketones,
- Lewis acid
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