Citation: Jian Feng Ji, Hui Bin Zhang, Wen Long Huang, Hai Qian, Jin Pei Zhou. A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors[J]. Chinese Chemical Letters, ;2010, 21(1): 67-69. doi: 10.1016/j.cclet.2009.08.009 shu

A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

a Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;
b Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 8 May 2009

Fund Project: We wish to thank Prof Yun Man Li, Dr Wei Rong Fang and Jing Kong for their assistance in bioactivities test. We also thank Jie Shen from Nanjing Normal University for the help with data analysis and language editing.

A convenient method for the synthesis of ezetimibe analogs as cholesterol absorption inhibitors was described. The key step in the synthesis was the intramolecular ring formation through Mitsunobu reaction. Furthermore, a new series of analogs was designed and synthesized.
- Ezetimibe,
- Synthesis,
- Cholesterol absorption inhibitor
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