Citation: Wei Wu, Xiao Yun Zhang, Shou Xing Kang. Rhodium-catalyzed selective [2+2+2] cyclizations of 1,6-diynes with monoynes leading to isoindolines and isobenzofurans[J]. Chinese Chemical Letters, ;2010, 21(1): 18-22. doi: 10.1016/j.cclet.2009.08.004 shu

Rhodium-catalyzed selective [2+2+2] cyclizations of 1,6-diynes with monoynes leading to isoindolines and isobenzofurans

Department of Chemistry, China University of Petroleum(East China), Qingdao 266555, China

Received Date: 20 April 2009

A highly efficient and selective [2+2+2] cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water/THF mixed solvent, affording isoindolines and isobenzofurans in good to excellent yields. The center atoms (N, O) in the diynes showed a significant effect for the cyclization.
- N,>N-dipropargyl p-toluenesulfonamide,
- Dipropargyl ether,
- Cyclization,
- Rhodium complex,
- Diynes
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