Citation: Su Yun Liu, Shigeo Katsumura. An improved synthesis of (-)-7-isopropyl-cis-1-amino-2-indanol the chiral auxiliary for 6π-azaelectrocyclization[J]. Chinese Chemical Letters, ;2009, 20(10): 1204-1206. doi: 10.1016/j.cclet.2009.05.024 shu

An improved synthesis of (-)-7-isopropyl-cis-1-amino-2-indanol the chiral auxiliary for 6π-azaelectrocyclization

Su Yun Liu ^a, ,
Shigeo Katsumura ^b

a Beijing Collab Pharma Co.Ltd., No.26 Jinyuan Street, Daxing Industrial Development Area, Beijing 102600, China;
b School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda, Hyogo 669-1337, Japan

Received Date: 28 March 2009

(-)-7-Isopropyl-cis-1-amino-2-indanol, a key chiral auxiliary and ligand in the highly stereo-selective asymmetric 6π-azaelectrocyclization,has been prepared previously by two methods.Each however involved using of one extreme condition,i.e.high temperature or high pressure, for the respective reaction.A modified reaction route employed mild condition for synthesis was presented in this report.
- Chiral,
- cis-1-Amino-2-indanol,
- Asymmetric dihydroxylation
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