Citation: Huai Ren Pan, Hai Jun Zhu, Zhong Rong Song, Xu Dong Zhang, Huai Cao. Molecular modeling of epsilon RNA from hepatitis B virus[J]. Chinese Chemical Letters, ;2009, 20(10): 1263-1266. doi: 10.1016/j.cclet.2009.05.018 shu

Molecular modeling of epsilon RNA from hepatitis B virus

a Modern Biological Research Center, Yunnan University, Kunming 650091, China;
b Department of Chemistry and Environmental Science, Chongqing University of Arts and Science, Chongqing 402168, China

Received Date: 4 January 2009

Fund Project: This research was partially supported by a grant from YNZY (No.2007JC02) to H.C.

An initial model of the HBV epsilon RNA was built by the Biopolymer module of Insight Ⅱ.While its three-dimensional structure was obtained through structure optimization based on molecular dynamics simulation, the two active sites were found.A comparison with the experimental result indicated that the active sites may be the binding sites of the epsilon RNA in the RT-epsilon interaction.The result will be helpful to further discussion about the mechanism of RT-epsilon interaction and the study of HBV genome replication.
- HBV,
- Epsilon RNA,
- RT-epsilon interaction,
- Molecular dynamics
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