Citation: Mohammad Reza Shushizadeh, Masumeh Kiany. Solvent-free alkylation of dimethyl malonate using benzyl alcohols catalyzed by FeCl₃/SiO₂[J]. Chinese Chemical Letters, ;2009, 20(9): 1068-1072. doi: 10.1016/j.cclet.2009.04.033 shu

Solvent-free alkylation of dimethyl malonate using benzyl alcohols catalyzed by FeCl₃/SiO₂

Mohammad Reza Shushizadeh ^a, ,
Masumeh Kiany ^b

a Department of Medicinal Chemistry, Ahvaz Jundishahpour University of Medical Science, PO Code 61357-73135, Ahvaz, Iran;
b Islamic Azad University, Ahvaz Science and Research Center, Ahvaz, Iran

Received Date: 12 February 2009

Activated methylene compound such as dimethyl malonate reacted readily with benzylic alcohols in the presence of ferric chloride/silica gel mixture (FeCl₃/SiO₂) under microwave irradiation to produce benzylic derivative of dimethyl malonate in high yields in solvent-free condition.
- Solvent-free,
- Alkylation,
- Activated methylene compounds,
- Benzyl alcohols,
- Microwave irradiation
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