Citation: M. Saranga Pani, M. Arjun, D. Sridhar, K. Srinivas, T. Raviprasad. N-Substituted benzoxazolyl ureas and thioureas in Biginelli reaction promoted by trifluoromethane sulfonic acid:An efficient and convenient synthesis of substituted benzoxazolyl 3,4-dihydropyrimidine (1H)-(thio)-ones[J]. Chinese Chemical Letters, ;2009, 20(8): 909-912. doi: 10.1016/j.cclet.2009.04.010 shu

N-Substituted benzoxazolyl ureas and thioureas in Biginelli reaction promoted by trifluoromethane sulfonic acid:An efficient and convenient synthesis of substituted benzoxazolyl 3,4-dihydropyrimidine (1H)-(thio)-ones

a Department of Pharmacy, Kakatiya University, Warangal 506009 (A.P.), India;
b Department of Chemistry, Kakatiya University, Warangal 506009 (A.P.), India

Received Date: 28 November 2008

Fund Project: The authors are thankful to Prof. S. Srihari, Head, Department of Chemistry, Kakatiya University,Warangal for the facilities and to the Director, Indian Institute of Chemical Technology, Hyderabad for recording 1H NMR and Mass Spectra.

An efficient synthesis of 3,4-dihydropyrimidine 2 (1H)-ones and thiones (3,4-DHPMs) core was prepared by one-pot threecomponent Biginelli condensation and which was catalyzed by trifluoromethane sulfonic acid. The classical Bignelli reaction has been extended by the use of N-substituted benzoxazolyl semicarbazides and thiosemicarbazides and this method has the advantage of excellent yields and short reaction times.
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