Citation: Zhong Wei Yao, Jun Xu, Da Wei Zhang, Hong Hui Lin, Chuan Qin Xia. DNA cleavage promoted by diethylenetriaminepentaacetic acid　(DTPA) derivatives　[J]. Chinese Chemical Letters, ;2009, 20(9): 1107-1110. doi: 10.1016/j.cclet.2009.03.049 shu

DNA cleavage promoted by diethylenetriaminepentaacetic acid　(DTPA) derivatives　

a College of Chemistry, Sichuan University, Chengdu 610064, China;
b School of Life Science, Sichuan University, Chengdu 610064, China

Received Date: 29 December 2008

Fund Project: his work was financially supported by the National Natural Science Foundation of China (No.20301011).

DTPA and its two derivatives were synthesized and used as catalysts in DNA cleavage. Under physiological conditions, a seriesof experiments have been done. The effects of DNA cleavage with three ligands were studied under different concentrations,cleavage time, and pH values. The results strongly suggested that the plasmid DNA (pUC 19) can be cleaved efficiently by CITC- DTPA. For the cleavage reaction catalyzed by CITC-DTPA, Form I DNA could convert to Form Ⅱ mostly, and the DNA-cleavage mechanism involved an oxidative pathway.
- TPA,
- Derivatives,
- DNA cleavage,
- Cleavage mechanism
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