Citation: Ming Zhao, Min Feng, Shu Fang Bai, Yuan Zhang, Wen Chao Bi, Hong Chen. Synthesis and antitumor activity of novel podophyllotoxin derivatives[J]. Chinese Chemical Letters, ;2009, 20(8): 901-905. doi: 10.1016/j.cclet.2009.03.043 shu

Synthesis and antitumor activity of novel podophyllotoxin derivatives

Ming Zhao ^a,b, ,
Min Feng ^a,b ,
Shu Fang Bai ^a ,
Yuan Zhang ^a ,
Wen Chao Bi ^a ,
Hong Chen ^a,b,c

a Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China;
b Graduate School of Tianjin Medical University, Tianjin 300070, China;
c TianJin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300162, China

Received Date: 18 November 2008

Fund Project: This work was supported by the National Natural Science Foundation of China (No.30873363), the Great Program of Science Foundation of Tianjin (No.06YFJZJCO2700) and Program of Science Foundation of Tianjin (No.08JCYBJC070000).

In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro.
- Podophyllotoxin derivatives,
- Chemosynthesis,
- Antitumor,
- Multidrug resistance
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