Citation: Shu Tao Ma, Rui Xin Ma, Rui Qing Xian, Bo Jiao. Synthesis of novel 15-membered macrolide dimers[J]. Chinese Chemical Letters, ;2009, 20(8): 931-934. doi: 10.1016/j.cclet.2009.03.015 shu

Synthesis of novel 15-membered macrolide dimers

a School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;
b Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China;
c Shandong Institute for Drug Control, Jinan 250000, China

Received Date: 22 December 2008

Fund Project: This research was supported by the National Natural Science Foundation of China (No.20872081), Natural Science Foundation of Shandong (No.Y2006C31) and Shandong Science and Technology Promotion Project (No.2005GG3202098).

A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S.pneumoniae encoded by erm gene.
- Macrolide,
- Azithromycin derivatives,
- Dimers,
- Synthesis
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