Citation: Tian Jiao Zhu, Lin Du, Peng Fei Hao, Zhen Jian Lin, Qian Qun Gu. Citrinal A, a novel tricyclic derivative of citrinin,from an algicolous fungus Penicillium sp. i-1-1[J]. Chinese Chemical Letters, ;2009, 20(8): 917-920. doi: 10.1016/j.cclet.2009.03.009 shu

Citrinal A, a novel tricyclic derivative of citrinin,from an algicolous fungus Penicillium sp. i-1-1

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China

Received Date: 8 December 2008

Fund Project: This work was financially supported by the Shandong Province Natural Science Fund (No.Z2006C13). The antitumor assay was performed at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

Citrinal A (1), a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b][1,4]dioxin-9(3H)-one skeleton, along with two known related compounds, citrinin (2) and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (3) were isolated from an algicolous fungus Penicillium sp. i-1-1. The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis. Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated.
- Citrinal,
- Algicolous fungus,
- Penicillium
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