Citation: Yong Qing Gao, Ning Zhou, Yu Jian Lv, Mao Shen Cheng, Ke Liang Liu. Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole[J]. Chinese Chemical Letters, ;2009, 20(6): 668-671. doi: 10.1016/j.cclet.2009.01.010 shu

Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole

a Schllo of pharmaceutical Engineering, Shenyang pharmaceutical University, Shenyang 11010, China;
b Beijing Institute of pharmacology and Toxicology, Beijing 100850, China

Received Date: 7 November 2008

Fund Project: We thank National Natural Science Foundation of China(No.30500629) for financial support.

The ureido-modification of the resin-bound a luteinizing hormone releasing hormone(LHRH) analogue was investigated by CDI-activating method.The amino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However,is its teminal amino group was partially converted to a hydantoin stucture due to the Natom of the adjacent amide bond.
- Urea moiety,
- N,N'-carbonyldiimidazole(CDI),
- Solid-phase,
- peptide
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