Citation: Qing Xiang Xiang, Li Qun Zhang, Xiao Qi Yu, Ru Gang Xie. Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. Chinese Chemical Letters, ;2009, 20(5): 523-526. doi: 10.1016/j.cclet.2009.01.001 shu

Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes

a Department of Chemistry and Life Science, Leshan Teachers College, Leshan 614004, China;
b Department of Chemistry, Sichuan University, Chengdu 610064, China

Received Date: 7 October 2008

Fund Project: This project is supported by the Science and Technology Department (No.04JY029-018) and Education Department of Sichuan Province (No.2006ZD049).

The activities of the catalytic hydrolysis of phosphate diester (BNPP)[bis (p-nitrophenyl)phosphate diester] and plasmid DNA (pUC18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(II) complex (composed of lipophilic group) as catalyst. The hydrolysis rate enhancement is up to 3.64×10⁴ fold. These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions.
- Catalytic hydrolysis,
- Macrocyclic polyamine,
- Zn(II)complex,
- BNPP,
- Plasmid DNA
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