Citation: Hai Feng Tang, Hou Wen Lin, Xiao Li Chen, Guang Cheng, Yue Ping Zhao, Ai Dong Wen. Cytotoxic triterpenoid saponins from Ardisia pusilla[J]. Chinese Chemical Letters, ;2009, 20(2): 193-196. doi: 10.1016/j.cclet.2008.10.030 shu

Cytotoxic triterpenoid saponins from Ardisia pusilla

a Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;
b Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
c Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China

Received Date: 10 July 2008

A new triterpenoid saponin, 3-O-{β-D-xylopyranosyl-(1→2)-b-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-a-L-arabinopyranosyl}-3β,16α,28α-trihydroxy-13β,28-epoxy-oleanan-30-al (ardipusilloside Ⅲ, 1), together with two known saponins,ardisiacrispins A (2) and B (3), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidences. Saponins 1 and 3 exhibited significant cytotoxicity against human glioblastoma U251MG cells.
- Ardisia pusilla,
- Triterpenoid saponin,
- Ardipusilloside Ⅲ,
- Cytotoxic activities
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