Citation: Le Wang, Yong Ye, Shang Bin Zhong, Yu Fen Zhao. Polydentate cyclotriphosphazene ligands: Design,synthesis and bioactivity[J]. Chinese Chemical Letters, ;2009, 20(1): 58-61. doi: 10.1016/j.cclet.2008.10.020 shu

Polydentate cyclotriphosphazene ligands: Design,synthesis and bioactivity

Le Wang ^a, ,
Yong Ye ^a,b ,
Shang Bin Zhong ^a ,
Yu Fen Zhao ^a,b

a Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;
b Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China

Received Date: 3 July 2008

Fund Project: We all thank the financial supports from the NNSFC (Nos. 20602032, 20732004 and 20572061).

Five multinuclear cyclotriphosphazene ligands were synthesized and tested for their cleavage activities to plasmid DNA. All of these new compounds were confirmed by MS, ¹H NMR, ³¹P NMR, ¹³C NMR and IR. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes were performed. The results revealed that these complexes could act as powerful catalysts under physiological conditions. The complexes 3b+Cu can effectively cleave DNA to nicked form, giving hydrolysis rate constant of 0.08/h under physiological conditions. An acid-base catalyzed DNA phosphate-diester hydrolysis mechanism was also proposed.
- Cyclotriphosphazene,
- Polydentate ligand,
- DNA cleavage,
- Hydrolysis
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