Citation: Jiao Xia Sun, Yan Feng Luo, Hui Peng, Zhi Wei Han. Design, synthesis and characterization of a novel pH-sensitive hydrogel[J]. Chinese Chemical Letters, ;2008, 19(12): 1475-1478. doi: 10.1016/j.cclet.2008.09.033 shu

Design, synthesis and characterization of a novel pH-sensitive hydrogel

a College of Chemistry & Chemical Engineering, Chongqing University, Chongqing 400030, China;
b College of Bioengineering, Chongqing University, Chongqing 400030, China

Received Date: 19 May 2008

Fund Project: This study was supported by Natural Science Foundation of Chongqing (No. CSTC2006BB5010) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 2007-1108).

A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediami-netetraacetic dianhydride (EDTAh) and butanediamine (BDA) with dicyclohexylcarbodiimide (DCC) as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by¹³C NMR, ¹H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.
- pH-sensitive hydrogel,
- Ethylenediaminetetraacetic dianhydride,
- Butanediarnine
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