Citation: E. Rajanarendar, A. Siva Rami Reddy, M. Srinivas. Expeditious method for the synthesis of novel 2,3,5,6-tetrahydrobenzo[g][1,3,5]oxadiazocine-4-thiones linked with isoxazole[J]. Chinese Chemical Letters, ;2008, 19(12): 1415-1418. doi: 10.1016/j.cclet.2008.09.025 shu

Expeditious method for the synthesis of novel 2,3,5,6-tetrahydrobenzo[g][1,3,5]oxadiazocine-4-thiones linked with isoxazole

Department of Chemistry, Kakatiya University, Warangal 506 009, India

Received Date: 5 June 2008

Fund Project: The authors are thankful to Prof. S. SriHari, Head, Department of Chemistry, Kakatiya University,Warangal for the facilities and to the Director, Indian Institute of Chemical Technology, Hyderabad for recording 1H NMR, 13C NMR and Mass Spectra.

Synthesis of novel 3-ary1-5-(3,5-dimethylisoxazol-4-y1)-2,3,5,6-tetrahydrobenzo[g][1,3,5]oxadiazocine-4-thiones 5 has been accomplished from 3,5-dimethylisoxazol-4-amine 1 by condensation with salicylaldehydes, followed by reduction, treatment with aryl isothiocyanates and subsequent smooth ring closure via acetal formation in the presence of formaldehyde.
- Isoxazoly1-2,3,5,6-tetrahydrobenzo[g][1,3,5]oxadiazocine-4-thiones,
- Ring closure,
- New methodology
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