Citation: Geng Xu, Zhan Zhu Liu. Synthesis of new chiral 1,2,3,4-tetrahydroisoquinoline β-amino alcohols from L-DOPA[J]. Chinese Chemical Letters, ;2008, 19(11): 1271-1273. doi: 10.1016/j.cclet.2008.09.024 shu

Synthesis of new chiral 1,2,3,4-tetrahydroisoquinoline β-amino alcohols from L-DOPA

Geng Xu ,
Zhan Zhu Liu

Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beifing 100050, China

Received Date: 21 May 2008

Four new chiral 1,2,3,4-tetrahydroisoquinoline-derived β-amino alcohols were synthesized from L-DOPA in good yields.The structures of the target compounds were confirmed by ¹H NMR,¹³C NMR and MS.
- β-Amino alcohol,
- Tetrahydroisoquinoline,
- L-DOPA,
- Pictet-Spengler reaction
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