Citation: Huan Sheng Chen, Xia Ping Ma, Zhi Ming Li, Quan Rui Wang, Feng Gang Tao. An effective synthesis of β-aryl substituted isotetronic acids via Suzuki coupling[J]. Chinese Chemical Letters, ;2008, 19(11): 1309-1311. doi: 10.1016/j.cclet.2008.09.016 shu

An effective synthesis of β-aryl substituted isotetronic acids via Suzuki coupling

Department of Chemistry, Fudan University, Shanghai 200433, China

Received Date: 11 June 2008

Fund Project: We are grateful to the Municipal Government of Shanghai (No. 03DZ19209) and Shanghai Hua-Yi Group for financial support.

lsotetronic acids are of great agricultural and pharmacological relevance and occur in a number of natural products.A convenient synthetic pathway to β-aryl substituted isotetronic acid derivatives was developed via Suzuki cross-coupling of the corresponding β-bromo substituted isotetronic acid derivatives with arylboronic acids under palladium acetate catalysis.Good to excellent yields have been achieved.
- Isotetronic acids,
- Palladium,
- Suzuki coupling,
- Arylboronic acids
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