Citation: Hua Zhang, Ling Li Wu, Quan Min Li, Xin Zhen Du. A novel method for the spectrophotometric determination of cefradine by using sodium nitroprusside as chromogenic reagent[J]. Chinese Chemical Letters, ;2008, 19(12): 1470-1474. doi: 10.1016/j.cclet.2008.09.014 shu

A novel method for the spectrophotometric determination of cefradine by using sodium nitroprusside as chromogenic reagent

Hua Zhang ^a,b, ,
Ling Li Wu ^a,c ,
Quan Min Li ^a ,
Xin Zhen Du ^b

a College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, China;
b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China;
c Henan Radio and Television University, Zhengzhou 453008, China

Received Date: 2 June 2008

A novel method is developed for the determination of cefradine by using sodium nitroprusside as chromogenic reagent. The experiment indicates that a russety product is formed by the reaction of cefradine with sodium nin'oprusside in basic solution, and the maximum absorption wavelength (λ_max) of russety product is 505 nm. And the sensitization of tetradecyl benzyl dimethyl ammonium chloride for the reaction of cefradine with sodium nitroprusside is remarkable. The apparent molar absorption coefficient (ε₅₀₅)is 2.81×10³ L/mol cm. The linear equation is A=0.0657+0.00804C (μg/mL) in the range of 1.50-55.0μg/mL of cefradine with a correlation coefficient r=0.9992, and the detection limit is 1.38μg/mL. This method has been applied to determine cefradine in capsule and tablet samples.
- Cefradine,
- Sodium nitroprusside,
- Chromogenic reagent,
- Spectrophotometry
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