Citation: Yuan Yuan Zhang, Ke Ping Xu, Dan Ren, Shao Rong Ge, Yu Liang Wang, Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters, ;2009, 20(1): 29-31. doi: 10.1016/j.cclet.2008.09.009 shu

Synthesis and antibacterial activities of pleuromutilin derivatives

a Department of Chemical Engineering, Sichuan University, Chengdu 610065, China;
b Department of Chemistry, Sichuan University, Chengdu 610064, China;
c Department of Life Science, Sichuan University, Chengdu 610064, China

Received Date: 11 June 2008

Six new pleuromutilin derivatives were designed and synthesized, confirmed by MS, IR and ¹H NMR techniques. And the antibacterial activities were primarily evaluated in vitro. The results indicated that most of the derivatives showed more potent activities against corresponding bacterial strains than that of pleuromutilin. Especially, compounds 4d and 5b had obvious activities against salmonella compared with pleuromutilin.
- Pleuromutilin,
- Derivatives,
- Synthesis,
- Antibacterial activities
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