Citation: Hong Wen Zhan, Jin Xian Wang, Xi Tian Wang. Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions[J]. Chinese Chemical Letters, ;2008, 19(10): 1183-1185. doi: 10.1016/j.cclet.2008.06.039 shu

Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions

Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 Anning Road(E.), Lanzhou 730070, China

Received Date: 7 April 2008

Fund Project: The work was supported by the Natural Science Foundation of China (No. 20272047, 20572086), the Natural Science Foundation of Gansu Province (No. 3ZS051-A25-001) and Key Laboratory of Eco-Environment-Related Polymer Material (Northwest Normal University), Ministry of Education of China.

Fifteen dihydropyrimidinthiones have been synthesized by microwave-assisted Biginelli reactions without any solvent of catalyst.The advantages of this novel protocol include the excellent yield,operational simplicity,short time and the avoidance of the use of organic solvents and catalysts.
- Focused microwave-assisted,
- Catalyst-and solvent-free,
- Synthesis,
- Dihydropyrimidinthiones
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