Citation: Shivaji S. Pawar, Deepak V. Dekhane, Murlidhar S. Shingare, Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, ;2008, 19(9): 1055-1058. doi: 10.1016/j.cclet.2008.06.028 shu

Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media

a Department of Chemistry, Vinyakrao Patil Mahavidyaia Vaijapur, Aurangabad 423701(M.S.), India;
b Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004(M.S.), India

Received Date: 21 March 2008

Fund Project: The authors are thankful to Head, Department of Chemistry, Vinayakrao Patil Mahavidyala Vaijapur 423701 (M.S.), India, for partial support of this work.

Glyoxylic acid (5 mol%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products.
- Glyoxylic acid,
- Benzimidazoles,
- Aqueous media,
- 2-Aryl-l-arylmethyl-lH-benzimidazoles,
- o-Phenylenediamines and aldehydes
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