Citation: Ling Ling Zhao, Yue Gai, Hisayoshi Kobayashi, Chang Qi Hu, Hui Ping Zhang. 5'-Hydroxyzearalenol, a new β-resorcylic macrolide from Fusarium sp. 05ABR26[J]. Chinese Chemical Letters, ;2008, 19(9): 1089-1092. doi: 10.1016/j.cclet.2008.06.025 shu

5'-Hydroxyzearalenol, a new β-resorcylic macrolide from Fusarium sp. 05ABR26

a Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China;
b Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 1130032, Japan

Received Date: 25 February 2008

Fund Project: This work was supported by the National Natural Science Foundation (No. 30371680) of the People's Republic of China. The authors thank Professor M. Chen (Centre of Analysis and Measurement of Fudan University) for work on the X-ray crystallographic analysis.

A new β-resorcylic maerolide, 5'-hydroxyzearalenol (1), was isolated from the culture broth of a marine-derived fungus Fusarium sp. 05ABR26. Three known compounds, zearalenone (2), 8'-hydroxyzearalenone (3) and zearalenol (4) were also isolated. The structure and relative stereochemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data. Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25 μg/mL, while compound 3 was much less active; however, 1 and 4 showed no obvious activity.
- 5'-Hydroxyzearalenol,
- Fusarium sp.,
- X-ray diffraction data,
- Pyricularia oryzae
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