Citation: un Liu, Jiao Wu, You Xing Zhao, Yuan Yuan Deng, Wen Li Mei, Hao Fu Dai. A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood[J]. Chinese Chemical Letters, ;2008, 19(8): 934-936. doi: 10.1016/j.cclet.2008.05.034 shu

A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood

a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;
b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

Received Date: 18 January 2008

Fund Project: This research was financially supported by National Basic Research Program of China (No.2007CB116306) and the Science and Technology Foundation of Chinese Academy of Agricultural Sciences (Nos.RKY0726 and RKY0442)

A new compound 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one (1) was isolated from the Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg].Its structure was elucidated on the basis of spectral data.Compound 1 showed cytotoxicity against human gastric cancer cell line (SGC-7901) in vitro by MTT method with the IC₅₀ value of 14.6 μg/mL.
- Chinese eaglewood,
- Aquilaria sinensis,
- Chromone,
- Cytotoxicity
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