Citation: Zhen Li Min, Yi Hua Zhang, Yi Sheng Lai, Si Xun Peng. One-pot synthesis of 2-(1-acyloxypentyl) benzoic acids[J]. Chinese Chemical Letters, ;2008, 19(8): 915-917. doi: 10.1016/j.cclet.2008.05.020 shu

One-pot synthesis of 2-(1-acyloxypentyl) benzoic acids

Center of Drug Discovery, China. Pharmaceutical University, Nanjing 210009, China

Received Date: 24 March 2008

A one-pot synthesis of 2-(1-acyloxypentyl) benzoic acids by trapping the carboxylate/alkoxide dianion with acylating reagents following Grignard addition with n-BuMgBr to 2-formylbenzoic acid was described.Compared with routine synthetic method, this novel procedure has the advantage of convenient operation and higher yields.
- One-pot synthesis,
- 3-n-Butyl-1(3H)-isobenzofuranone,
- 2-(1-Hydroxypentyl)benzoic acid,
- 2-(1-Acyloxypentyl)-benzoic acids
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