Citation: Liang You, Wan Nian Zhang, Zhen Yuan Miao, Wei Guo, Xiao Ying Che, Wen Ya Wang, Chun Quan Sheng, Jiang Zhong Yao, Ting Zhou. Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues[J]. Chinese Chemical Letters, ;2008, 19(7): 811-813. doi: 10.1016/j.cclet.2008.05.011 shu

Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 7 March 2008

Fund Project: This research was supported by the National Natural Science Foundation of China (No.30371689)Shanghai Major Program Science and Technology Foundation (No.064319009) and Shanghai Leading Academic Discipline Project (No.B906).

Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method.The results showed that some of the compound had higher antitumor activity than iritecan.
- Homocamptotbecin,
- Amino acids ester,
- Antitumor activity,
- Synthesis
1. [1]
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2. [2]
  Yulong Shi , Fenbei Chen , Mengyuan Wu , Xin Zhang , Runze Meng , Kun Wang , Yan Wang , Yuheng Mei , Qionglu Duan , Yinghong Li , Rongmei Gao , Yuhuan Li , Hongbin Deng , Jiandong Jiang , Yanxiang Wang , Danqing Song . Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1. Chinese Chemical Letters, 2024, 35(5): 108792-. doi: 10.1016/j.cclet.2023.108792
3. [3]
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4. [4]
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5. [5]
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6. [6]
  Min-Hang Zhou , Jun Jiang , Wei-Min He . EDA-complexes-enabled photochemical synthesis of α-amino acids with imines and tetrabutylammonium oxalate. Chinese Chemical Letters, 2025, 36(1): 110446-. doi: 10.1016/j.cclet.2024.110446
7. [7]
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8. [8]
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9. [9]
  Xinyi Zhang , Kai Ren , Yanning Liu , Zhenyi Gu , Zhixiong Huang , Shuohang Zheng , Xiaotong Wang , Jinzhi Guo , Igor V. Zatovsky , Junming Cao , Xinglong Wu . Progress on Entropy Production Engineering for Electrochemical Catalysis. Acta Physico-Chimica Sinica, 2024, 40(7): 2307057-0. doi: 10.3866/PKU.WHXB202307057
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11. [11]
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12. [12]
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13. [13]
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14. [14]
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15. [15]
  Hong-Tao Ji , Yu-Han Lu , Yan-Ting Liu , Yu-Lin Huang , Jiang-Feng Tian , Feng Liu , Yan-Yan Zeng , Hai-Yan Yang , Yong-Hong Zhang , Wei-Min He . Nd@C₃N₄-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines. Chinese Chemical Letters, 2025, 36(2): 110568-. doi: 10.1016/j.cclet.2024.110568
16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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