Citation: Jie Zhou, Bai Ling Xu. Three-component one-pot synthesis of 1,2,3,4-tetrahydroquinoline derivatives in hexafluoroisopropanol[J]. Chinese Chemical Letters, ;2008, 19(8): 921-924. doi: 10.1016/j.cclet.2008.05.008 shu

Three-component one-pot synthesis of 1,2,3,4-tetrahydroquinoline derivatives in hexafluoroisopropanol

Jie Zhou ,
Bai Ling Xu

Institute of Materia. Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Belting 100050, China

Received Date: 25 March 2008

Fund Project: We thank the National Natural Science Foundation of China (No.30672540) and NSF of Beijing (No.7072048) for financial support

The one-pot aza-Diels-Alder reaction of substituted aromatic amines, ethyl glyoxylate and benzyl vinylcarbamate or N-benzyloxycarbonyl 2-pyrroline was conducted in hexafluoroisopropanol, providing the desired 1,2,3,4-tetrahydroquinline derivatives in moderate yields.
- Aza-Diels-Alder reaction,
- Tetrahydroquinoline,
- Hexafluoroisopropanol (HFIP),
- Fluorinated solvent
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