Citation: Hai Ling Hao, Pi Sun, Guang Xing Wang, Kyoji Fruta, Masaaki Suzuki. Synthesis of both epimeric triacid ananlogs of kainic acid[J]. Chinese Chemical Letters, ;2008, 19(3): 269-272. doi: 10.1016/j.cclet.2008.01.003 shu

Synthesis of both epimeric triacid ananlogs of kainic acid

a Institute of Chemistry and Chemical Engineering, Hennan Institute of Science and Technology, Xinxiang, Henan 453003, China;
b Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu 501-1193, Japan

Received Date: 18 September 2007

Fund Project: This work was supported in part by a Grant-in-Aid for Creative Scientific Research " In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs" (No. 13NP0401), from the Ministry of Education, Culture, Sports, Science and Technology, Japan. G.X.W. thanks the JSPS postdoctoral fellowship for Foreign Researchers.

A practical and cheap method for synthesis of C-4 carboxylic acid substituted kainic acid analogue 5 and its epimer 6 from trans-4-hydroxyproline is described. Using this method, more interesting intermediates and analogues could be obtained easily.
- Trans-4-hydroxyproline,
- Kainic acid analogue,
- Practical synthesis
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