Citation: Li Qiao, Yu Zhi Zhou, Huan Chen, Jia Qing Cao, Yue Hu Pei. One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans[J]. Chinese Chemical Letters, ;2008, 19(3): 299-301. doi: 10.1016/j.cclet.2007.12.019 shu

One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 10 September 2007

Fund Project: The authers thank Yi Sha and Wen Li for the measurements of NMR spectra.

Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.
- Biotransformation,
- Cinobufagin,
- 7β,12β-Dihydroxylcinobufagin,
- Cunninghamella elegans
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