Citation: Xiao Ying Yang, Zun Feng Liu, Jie Mao, Shu Jing Wang, Yan Feng Ma, Yong Sheng Chen. The preparation of functionalized single walled carbon nanotubes as high efficiency DNA carriers[J]. Chinese Chemical Letters, ;2007, 18(12): 1551-1553. doi: 10.1016/j.cclet.2007.10.006 shu

The preparation of functionalized single walled carbon nanotubes as high efficiency DNA carriers

a School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China;
b Center for Nanoscale Science and Technology and Key Laboratory for Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

Received Date: 26 June 2007

Fund Project: We gratefully acknowledge the financial support from MOE (no.20040055020) and NSF founding of Tianjin city (no.07JCYBJC01700).

The positively charged single walled carbon nanotubes (SWNTs⁺) were prepared by conjugating with-CONH-C₆H₁₂-NH₃⁺. The double strand DNA (dsDNA) chains were loaded onto SWNTs⁺ via the electrostatic interactions. SWNTs⁺ shows improved loading efficiency (353.5 μg/mg) toward dsDNA compared with that of charged free single walled carbon nanotubes (SWNTs)(82.9 μg/mg).
- Single walled carbon nanotubes,
- DNA,
- Carrier
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