Citation: Gu He, Li Guo. Synthesis and theoretical study of first generation CCK-functional dendrimers[J]. Chinese Chemical Letters, ;2007, 18(12): 1505-1508. doi: 10.1016/j.cclet.2007.10.004 shu

Synthesis and theoretical study of first generation CCK-functional dendrimers

Gu He ,
Li Guo

Key Laboratory of Drug Targeting of Ministry of Education and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 19 June 2007

Fund Project: We are grateful for the financial support of National Natural Science Foundation of China (No.20472055).

A convenient synthesis and theoretical study of five CCK-functional dendrimers is described. The dendritic cores were linked with the CCK (Trp-Met-Asp (OBn)-PheNH₂) fragment by forming amide bonds to give five target molecules. The structures of CCK-functional dendrimers were characterized by NMR, MS spectrum and predicted using molecular mechanics and PM3 semiempirical molecular orbital theory.
- Dendrimer,
- CCK,
- Synthesis,
- Molecular mechanics,
- Semi-empirical molecular orbital theory
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