Citation: Hong Yu Shi, Rui Juan Song, Yu Fu, Na Yao, Yuan De Long, Tian Bao Huang. A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography[J]. Chinese Chemical Letters, ;2007, 18(11): 1392-1394. doi: 10.1016/j.cclet.2007.09.016 shu

A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography

Hong Yu Shi ^a,b, ,
Rui Juan Song ^a,b ,
Yu Fu ^a,b ,
Na Yao ^a,b ,
Yuan De Long ^a ,
Tian Bao Huang ^a

a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
b Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received Date: 26 June 2007

A novel chiral stationary phase (CSP1) for ligand-exchange chromatography (CLEC) was prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol group on the surface of silica gel, and then introducing L-Pro as a chiral selector and hydrophobic octyl group to the silica gel surface simultaneously. The enantioseparations of 14 DL-amino acids on CSP1 were achieved with the enantioselectivity α ranging from 1.09 to 2.44 and the resolution Rs being between 0.8 and 6.3. The chromatographic performances of CSP1 with the bonded phase (CSP2) prepared using reference method were compared. The results showed that the column efficiency and resolution Rs of chiral stationary phase could be improved by using the above modifying method.
- Ligand-exchange chromatography,
- Chiral stationary phase,
- Amino acids,
- Enantiomerie resolution
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