Citation: Rui Juan Song, Yu Fu, Na Yao, Yuan De Long, Tian Bao Huang. Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography[J]. Chinese Chemical Letters, ;2007, 18(10): 1250-1252. doi: 10.1016/j.cclet.2007.07.022 shu

Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography

Rui Juan Song ^a,b, ,
Yu Fu ^a,b ,
Na Yao ^a,b ,
Yuan De Long ^a ,
Tian Bao Huang ^a

a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
b Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received Date: 14 May 2004

Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparations of DL-amino acids and DL-hydroxyl acids. The resolutions were achieved by using water containing 2.0×10^-4 mol/L of CuAc₂ as a mobile phase, column temperature of 40℃, flow rate of 1.0 mL/min and detection at UV 254 mn. The elution order of D-isomer before L-isomer was observed for all DL-amino acids resolved except DL-Pro.
- Chiral stationary phase,
- Ligand-exchange chromatography,
- DL-Hydroxyl acid,
- Surface grafting,
- DL-Amino acid
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