Citation: Yue Mei Jia, Xiao Mei Liang, Xue Qin Fang, Jing Ping Wu, Dao Quan Wang, Chang Hui Rui, Xian Lin Fan, Hai Yan Zhao, Yun Xia Wang. Synthesis of 4"-benzyloxyimino-4"-deoxyavermectin B1a derivatives[J]. Chinese Chemical Letters, ;2007, 18(8): 895-898. doi: 10.1016/j.cclet.2007.06.003 shu

Synthesis of 4"-benzyloxyimino-4"-deoxyavermectin B1a derivatives

a Department of Applied Chemistry, China Agricultural University, Beijing 100094, China;
b Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100094, China

Received Date: 29 March 2007

Fund Project: We acknowledge financial support of this investigation by the National Basic Research Program of China (No. 2003CB114407).

Six new 4"-benzyloxyimino-4"-deoxyavermectin B1a derivatives were synthesized from avermectin B1a by the selective protection of C-5-hydroxy group, oxidation of C-4"-hydroxy group, and deprotection followed by reaction with O-substituted hydroxylamine hydrochlorides. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR and MS. Insecticidal activities of the derivatives against Phopalosiphum pseudobrassicae, Spodoptera exigua and Pluteua xylosteua were evaluated.
- Avermectin,
- Synthesis,
- 4"-Benzyloxyimino-4"-deoxyavermectin B1a derivatives,
- Insecticidal activity
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