Citation: Chang Qing Shi, Zhang Qin Liu, Wen Qing Lin, Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters, ;2007, 18(8): 899-901. doi: 10.1016/j.cclet.2007.05.052 shu

Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

a Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 9 April 2007

Fund Project: The authors thank the 100 Talents program of Chinese Academy of Sciences, the Chengdu Institute of Organic Chemistry, and the Graduate School of the Chinese Academy of Sciences for financial support of this work.

A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.
- Indoles,
- Synthesis,
- Kinesin spindle protein inhibitor,
- Cytotoxicity,
- Cancer treatment
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