Citation: Ying Jun Li, Ya Zhen Sun, Yong Ting Xu, Kun Jin, Li Ping Wen, Ni Bo Hou, Xiao Xiao Sun. One-pot synthesis of 2,5-disubstituted-l,3,4-thiadiazoles under ultrasonic irradiation[J]. Chinese Chemical Letters, ;2007, 18(9): 1047-1048. doi: 10.1016/j.cclet.2007.05.049 shu

One-pot synthesis of 2,5-disubstituted-l,3,4-thiadiazoles under ultrasonic irradiation

a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China;
b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China

Received Date: 29 March 2007

A facile one-pot synthesis of 2, 5-disubstituted-1, 3, 4-thiadiazoles was achieved by ultrasonic irradiation of a mixture of lnaphthylacetyl chloride, NH₄CNS, CH₂Cl₂ and PEG-400 for 1.5 h at 10-20℃ and subsequent irradiation for 1.5 h in the presence of N-arylglycine hydrazides. This method requires short time and gives thiadiazoles in high yields.
- One-pot,
- Ultrasonic irradiation,
- 2,5-Disubstituted-1,3,4-thiadiazoles,
- Synthesis
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