Citation: Li Ming Qiang, Shu Xia Cao, Yan Chun Guo, Xin Cheng Liao, Yu Fen Zhao. Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides[J]. Chinese Chemical Letters, ;2007, 18(8): 939-942. doi: 10.1016/j.cclet.2007.05.032 shu

Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

a Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;
b Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

Received Date: 24 January 2007

Fund Project: The authors would like to thank the National Natural Science Foundation of China (Nos. 20572061, 20672104), the Chinese Ministry of Education and Zhengzhou University for financial support.

The reactions of four different N-(O, O'-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-L-α-alanine (DIPPL-α-Ala), N-phosphoryl-D-α-alanine (DIPP-D-α-Ala), N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba), and four nucleosides, adenosine (A), guanosine (G), cytdine (C) and uridine (U), were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and HPLC/ESI-MS. DIPP-L-α-Ala and D1PP-D-α-Ala produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-Ala and DIPP-γ-Aba gave no relevant products.
- N-phosphoryl amino acids,
- Nucleosides,
- Dinucleotides
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