Citation: She Ying Dong, Chun Xia Xue, Ting Lin Huang. Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution[J]. Chinese Chemical Letters, ;2007, 18(6): 726-729. doi: 10.1016/j.cclet.2007.04.033 shu

Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

a College of Sciences, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China;
b School of Environment and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China

Fund Project: The authors gratefully acknowledge the support for this research by the Nature Science Foundation of Shaanxi Province in China (No. 2005B28).

The interaction between clarithromycin (CAM) and bovine serum albumin (BSA) was investigated using linear-sweep voltammetry in pH 7.4 phosphate buffer solution where CAM caused two irreversible reduction waves P₂ and P₃ on mercury electrode.The study showed that the formation constant and formation ratio for the interaction between CAM and BSA were 1.51×10¹² and 3:1 for P₂, 4.53×10⁵ and 1:1 for P₃, respectively.The ion strength enhanced the hydrophobic interaction between CAM and BSA.
- Clarithromycin,
- Bovine serum albumin,
- Interaction,
- Linear-sweep voltammetry
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