Citation: Qing lie Zhao, Yan Song, Hong Gang Hu, Shi Chong Yu, Qiu Ye Wu. Design, synthesis and antifungal activity of novel triazole derivatives[J]. Chinese Chemical Letters, ;2007, 18(6): 670-672. doi: 10.1016/j.cclet.2007.04.019 shu

Design, synthesis and antifungal activity of novel triazole derivatives

School of Pharmary, Second Military Medical University, Shanghai 200433, China

Received Date: 27 February 2007

Fund Project: The work was supported by the National Natural Science Foundation of China (No. 30572257).

Twenty-three 1-(1H-1, 2, 4-triazole-1-yl)-2-(2, 4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase.In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
- Antifungal,
- Tiazole,
- Synthesis
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