Citation: Nian Guang Li, Qi Dong You, Xue Feng Huang, Jin Xin Wang, Qing Long Guo, Xiao Guang Chen, Yan Li, Hong Yan Li. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. Chinese Chemical Letters, ;2007, 18(6): 659-662. doi: 10.1016/j.cclet.2007.04.010 shu

Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid

a Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;
b Department of Physiology, China Pharmaceutical University, Nanjing 210009, China;
c Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China

Received Date: 10 January 2007

Fund Project: The authors thank the 863 High-Tech Project of China (Nos. 2002AA2Z3112 and 2004AA2Z3A10), the Key Projects of Science and Technology Research of Ministry of Education of PRC (No. 2006-106094) and the Projects of Natural Science Foundation of Jiangsu Province (No. BK2006149) for financial support.

Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method.The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities.The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
- Gambogic acid,
- Small molecular compounds,
- Antitumor activity
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