Citation: Cheng Jiang, Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters, ;2007, 18(6): 647-650. doi: 10.1016/j.cclet.2007.04.002 shu

An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation

Cheng Jiang ,
Qi Dong You

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 21 December 2006

Fund Project: This work was financially supported by a grant from "The Six Top Talents" of Jiangsu Province (no. 06-C-023) and Specialized Research Fund for the Doctoral Program of Higher Education P.R.C. (no. 20060316006).

An efficient synthesis of 3, 4-dihydropyrirnidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea (thiourea) without solvent under the irradiation of microwave is described.Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).
- Biginelli reaction,
- 3, 4-Dihydropyrimidone,
- Microwave,
- Solvent-free,
- Formic acid
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